منابع مشابه
Fragility of pulmonary capillaries.
Although the pulmonary capillaries were discovered in 1661, the ultrastructure of the wall was not elucidated until 60 years ago. Electron micrographs then showed that only 0.2 μm of tissue separated the capillary endothelium from the alveolar space over much of the area. In retrospect this vanishingly small protective layer should have alerted physiologists to the potential fragility of the ca...
متن کاملIncreased fragility of pulmonary capillaries in newborn rabbit.
The pulmonary capillaries of neonatal lungs are potentially vulnerable to stress failure because of the complex changes in the pulmonary circulation that occur at birth. We perfusion fixed the lungs from nine anesthetized newborn rabbits at capillary transmural pressures (P(tm)) of 5 +/- 5, 10 +/- 5, and 15 +/- 5 cmH(2)O. Normal microscopic appearances were seen at P(tm) values of 5 +/- 5 and 1...
متن کاملVulnerability of pulmonary capillaries during severe exercise.
I t is remarkable that it has taken so long to recognise how vulnerable the pulmonary capillaries are to mechanical failure during strenuous exercise. After all, the extreme thinness of the capillary wall was appreciated when the first electron micrographs were obtained by Low in 1952. We now know that the total area of the blood-gas barrier (BGB) in the human lung is 50–100 m and that for more...
متن کاملPulmonary capillaries are recruited during pulsatile flow.
Capillaries recruit when pulmonary arterial pressure rises. The duration of increased pressure imposed in such experiments is usually on the order of minutes, although recent work shows that the recruitment response can occur in <4 s. In the present study, we investigate whether the brief pressure rise during cardiac systole can also cause recruitment and whether the recruitment is maintained d...
متن کاملThe nature of leukocyte shape changes in the pulmonary capillaries.
The size discrepancy between leukocytes [white blood cells (WBCs)] and pulmonary capillaries requires WBCs to deform. We investigated the persistence of this deformation on cells leaving the capillary bed and the role played by the cytoskeleton. Isolated rabbit lungs were perfused in situ via the pulmonary artery with effluent fractions collected from the left ventricle. Washout curves from cel...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2013
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.00229.2013